(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid
Fmoc-D-His-OH
CAS: 157355-79-8
Molecular Formula: C21H19N3O4
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid - Names and Identifiers
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid - Physico-chemical Properties
| Molecular Formula | C21H19N3O4 |
| Molar Mass | 377.39 |
| Density | 1.372±0.06 g/cm3(Predicted) |
| Melting Point | >128oC (dec.) |
| Boling Point | 706.7±60.0 °C(Predicted) |
| Solubility | Acetic Acid (Slightly), Aqueous Base (Slightly), DMSO (Slightly), DMF (Slightly, |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| pKa | 3.26±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ |
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid - Introduction
Fmoc-D-His-OH is a compound mainly used in the fields of biochemistry and organic synthesis. The following is an introduction to its nature, use, preparation and safety information:
Nature:
Fmoc-D-His-OH is a white or off-white crystalline solid with a distinctive odor. It is soluble in organic solvents such as dichloromethane, acetic anhydride and ethanol, but insoluble in water.
Use:
Fmoc-D-His-OH is an important amino acid protecting group, which is often used in peptide and protein synthesis. It can construct a polypeptide chain by D-histidine and other amino acids with Fmoc protecting group and be removed from the amino acid at the end of the synthesis by a deprotection operation.
Method:
Fmoc-D-His-OH can be prepared by reacting L-histidine with Fmoc-OSu(N-9-furoyl-L-histidine ester). This reaction, which is essentially carried out in sodium carbonate solution, produces the Fmoc-histidine product. The Fmoc-D-His-OH can then be obtained by appropriate extraction and crystallization steps.
Safety Information:
The Fmoc-D-His-OH is substantially safe under normal operating conditions. However, like many compounds, it also has a certain degree of danger. When handling, follow appropriate safety practices, such as wearing suitable protective equipment (such as gloves, glasses and laboratory coats) to avoid inhalation, ingestion or contact with skin. During use, the laboratory should be kept well ventilated, and care should be taken to avoid contact with strong oxidants and corrosives. In the event of an accident, immediately flush the affected area thoroughly with plenty of water and seek medical attention.
Nature:
Fmoc-D-His-OH is a white or off-white crystalline solid with a distinctive odor. It is soluble in organic solvents such as dichloromethane, acetic anhydride and ethanol, but insoluble in water.
Use:
Fmoc-D-His-OH is an important amino acid protecting group, which is often used in peptide and protein synthesis. It can construct a polypeptide chain by D-histidine and other amino acids with Fmoc protecting group and be removed from the amino acid at the end of the synthesis by a deprotection operation.
Method:
Fmoc-D-His-OH can be prepared by reacting L-histidine with Fmoc-OSu(N-9-furoyl-L-histidine ester). This reaction, which is essentially carried out in sodium carbonate solution, produces the Fmoc-histidine product. The Fmoc-D-His-OH can then be obtained by appropriate extraction and crystallization steps.
Safety Information:
The Fmoc-D-His-OH is substantially safe under normal operating conditions. However, like many compounds, it also has a certain degree of danger. When handling, follow appropriate safety practices, such as wearing suitable protective equipment (such as gloves, glasses and laboratory coats) to avoid inhalation, ingestion or contact with skin. During use, the laboratory should be kept well ventilated, and care should be taken to avoid contact with strong oxidants and corrosives. In the event of an accident, immediately flush the affected area thoroughly with plenty of water and seek medical attention.
Last Update：2024-04-09 20:45:29
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Product Name: FMOC-D-HIS-OH Visit Supplier Webpage Request for quotationCAS: 157355-79-8
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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